Raf-1 Activation Prevents Caspase 9 Processing Downstream of Apoptosome Formation
نویسندگان
چکیده
منابع مشابه
Raf-1 Activation Prevents Caspase 9 Processing Downstream of Apoptosome Formation
In many cell types, growth factor removal induces the release of cytochrome-c from mitochondria that leads to activation of caspase-9 in the apoptosome complex. Here, we show that sustained stimulation of the Raf-1/MAPK1,3 pathway prevents caspase-9 activation induced by serum depletion in CCL39/ΔRaf-1:ER fibroblasts. The protective effect mediated by Raf-1 is sensitive to MEK inhibition that i...
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ژورنال
عنوان ژورنال: Journal of Signal Transduction
سال: 2011
ISSN: 2090-1739,2090-1747
DOI: 10.1155/2011/834948